ODCs

Cytoscape Web

Click node...

Polycythemia vera

1 OMIM reference -
3 associated genes
25 signs/symptoms

PROTEIN INTERACTIONS: 1
COMMON SIGNS: 3

Cutaneous mastocytoma

1 associated gene
11 signs/symptoms

Polycythemia vera

Cutaneous mastocytoma

JAK2	(UniProt - OMIM)		KIT	(UniProt - OMIM)
MPL	(UniProt - OMIM)
TET2	(UniProt - OMIM)


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	JAK2	(0.85)	KIT

Citations in the biomedical literature:

Polycythemia vera		Cutaneous mastocytoma
	Synonym(s): - Acquired primary erythocytosis - Erythremia - Osler-Vaquez disease - PV - Polycythemia rubra vera - Vaquez disease		Synonym(s): - Cutaneous local mastocytoma - Multiple mastocytoma - Solitary mastocytoma

	Classification (Orphanet): - Rare hematologic disease - Rare oncologic disease		Classification (Orphanet): - Rare allergic disease - Rare hematologic disease - Rare oncologic disease - Rare skin disease

	Classification (ICD10): - Neoplasms -		Classification (ICD10): - Congenital malformations, deformations and chromosomal abnormalities -

	Epidemiological data: Class of prevalence: 1-5 / 10 000 Average age onset: variable Average age of death: normal Type of inheritance: sporadic		Epidemiological data: Class of prevalence: unknown Average age onset: variable Average age of death: normal Type of inheritance: sporadic

	External references: 1 OMIM reference - 1 MeSH reference: D011087		External references: No OMIM references 1 MeSH reference: D054705


COMMON SIGNS	- Acute abdominal pain / colic - Facial pain / cephalalgia / migraine - Pruritus / itching

Polycythemia vera		Cutaneous mastocytoma
	Very frequent - Acute leukemia - Angor pectoris / myocardial infarction - Chronic arterial hypertension - Dizziness - Ecchymoses - Epistaxis / nose bleeding - Erythema / erythematous lesions / erythroderma / polymorphous erythema - Gastrointestinal bleeding / hemorrhage / hematemesis / melena / rectorrhagia - Gingivorrhagia / gingival bleeding - Hepatomegaly / liver enlargement (excluding storage disease) - Myelodysplastic syndrome - Splenomegaly - Tinnitus - Weight loss / loss of appetite / break in weight curve / general health alteration Frequent - Articular / joint pain / arthralgia - Asthenia / fatigue / weakness - Respiratory distress / dyspnea / respiratory failure / lung volume reduction Occasional - Arterial embolism / thrombosis - Claudication / pain on mastication / while chewing - Portal hypertension - Transient cerebral ischemia / stroke - Venous thrombosis / phlebitis / thrombophlebitis		Very frequent - Abnormal pigmentary skin changes / skin pigmentation anomalies - Macules - Mastocytosis - Subcutaneous nodules / lipomas / tumefaction / swelling - Urticaria - Vesicles / bullous / exsudative lesions / bullous / cutaneous / mucosal detachment Frequent - Thick skin / pachydermia / orange skin Occasional - Hot flushes / sensation of cold